The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells
J. E. Corn, S. Kabir, J. Cidado, C. Andersen, C. Dick, P.-C. Lin, T. Mitros, H. Ma, S. H. Baik, M. Belmonte, L. Drew
The paper identifies the CUL5 ubiquitin ligase complex as a mediator of resistance to MCL1 and CDK9 inhibitors in lung cancer cells by regulating pro-apoptotic proteins.
bioRxiv · Jan 11, 2019Cancer Biology