Author

L. Endler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:transcription & RNA processing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Bergthaler· 3 shared B. Agerer· 3 shared A. Lercher· 2 shared A. Popa· 2 shared A. Zoufaly· 2 shared C. Bock· 2 shared E. Pawelka· 2 shared J.-W. Genger· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. Bergthaler

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

R. Gawish, P. Starkl, L. Pimenov, A. Hladik, K. Lakovits, F. Oberndorfer, S. J. F. Cronin, A. Ohradanova-Repic, G. Wirnsberger, B. Agerer, L. Endler, T. Capraz, J. W. Perthold, A. Hagelkruys, N. Montserrat, , S. Knapp

This paper develops a mouse-adapted SARS-CoV-2 strain, maVie16, to model COVID-19 in mice, showing that ACE2 is critical for disease and that blocking TNF/IFNγ reduces immunopathology.

bioRxiv · Aug 9, 2021Immunology

SARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes

B. Agerer, M. Koblischke, V. Gudipati, M. Smyth, A. Popa, J.-W. Genger, L. Endler, D. M. Florian, V. Muehlgrabner, A. Lercher, P. Gattinger, R. Torralba-Gombau, T. Penz, I. Fae, S. Wenda, , A. Bergthaler

The paper identifies mutations in SARS-CoV-2 that reduce MHC-I binding and CD8+ T cell recognition, suggesting escape from immune surveillance.

bioRxiv · Dec 18, 2020 · PreprintImmunology

Mutational dynamics and transmission properties of SARS-CoV-2 superspreading events in Austria

A. Popa, J.-W. Genger, M. Nicholson, T. Penz, D. Schmid, S. W. Aberle, B. Agerer, A. Lercher, L. Endler, H. Colaco, M. Smyth, M. Schuster, M. Grau, F. Martinez Jimenez, O. Pich, , A. Bergthaler

This study analyzes SARS-CoV-2 superspreading events in Austria using genomic and epidemiological data to understand viral transmission and mutation dynamics.

Science Translational Medicine · Dec 9, 2020Peer-reviewedMicrobiology