ImmunologybioRxivPreprint
Mast cell-derived BH4 is a critical mediator of postoperative pain
P. Starkl, G. Jonsson, T. J. Artner…·S. J. F. Cronin
This study identifies mast cell-derived BH4 as a key mediator of postoperative pain, showing that substance P triggers BH4-dependent serotonin release in mast cells, and blocking substance P reduces pain.
DOI 10.1101/2023.01.24.525378