Author

L. Flint

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

T. Parish· 3 shared A. Korkegian· 2 shared A. J. Manning· 1 shared A. M. Lande· 1 shared A. Valdez· 1 shared B. Berube· 1 shared B. C. Curtis· 1 shared C. D. Shelton· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

T. Parish

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieus

B. C. Curtis, C. H. Spurrell, L. Flint, A. M. Lande, M. Leonardi, J. M. Rosser, A. Valdez, N. Murren, T. Chai, M. Fitzgerald, J. Martinez-Reyes, C. P. Saxby, S. K. Oda, M. C. Jensen

This paper develops a CRISPRa-based method to identify genes enhancing CAR T cell survival in different tumor environments.

bioRxiv · Mar 16, 2024 · PreprintImmunology

Triazolopyrimidines target aerobic respiration in Mycobacterium tuberculosis

C. D. Shelton, M. B. McNeil, L. Flint, D. Russell, B. Berube, A. Korkegian, Y. Ovechkina, T. Parish

This study identifies triazolopyrimidines as inhibitors of Mycobacterium tuberculosis cytochrome bc1 complex, showing resistance linked to QcrB mutations and efficacy against intracellular bacteria.

bioRxiv · Oct 18, 2021Microbiology

Identification of novel chemical scaffolds that inhibit the growth of Mycobacterium tuberculosis in macrophages

S. Ahmed, A. J. Manning, L. Flint, D. Awasthi, T. Parish

This study identifies five chemical classes that inhibit intracellular Mycobacterium tuberculosis growth in macrophages, with some also active against extracellular bacteria.

bioRxiv · Sep 28, 2021Microbiology

InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis

L. Flint, A. Korkegian, T. Parish

The paper tests two diazaborine molecules against non-replicating Mycobacterium tuberculosis and finds they reduce viability by >3 logs in 21 days.

bioRxiv · Aug 19, 2020Microbiology