M. Leonardi

Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieus

This paper develops a CRISPRa-based method to identify genes enhancing CAR T cell survival in different tumor environments.

tidysdm: leveraging the flexibility of tidymodels for Species Distribution Modelling in R

tidysdm provides an R package for species distribution modelling using tidymodels, enabling flexible and unified model fitting, tuning, and validation across multiple algorithms.

Establishment and validation of a High-throughput Micro-Neutralization assay for Respiratory Syncytial Virus (subtypes A and B)

This paper validates a high-throughput micro-neutralization assay for detecting neutralizing antibodies against Respiratory Syncytial Virus subtypes A and B.

Niche conservatism in a generalist felid: low differentiation of the climatic niche among subspecies of the leopard (Panthera pardus)

This study uses species distribution models to compare the climatic niches of leopard subspecies, finding low differentiation and suggesting niche conservation despite geographic dispersal.

pastclim: an R package to easily access and use paleoclimatic reconstructions

pastclim provides an R package to access and use paleoclimatic reconstructions for the last 120,000 and 800,000 years, simplifying data extraction and analysis for researchers.

COVID-19 mRNA third dose induces a unique hybrid immunity-like antibody response

This study examines how a third mRNA vaccine dose enhances neutralizing antibody responses against SARS-CoV-2 variants by expanding specific B cell germlines and altering the antibody repertoire.

Hybrid immunity improves B cell frequency, antibody potency and breadth against SARS-CoV-2 and variants of concern

This study compares B cell responses in naive and convalescent individuals after SARS-CoV-2 vaccination, showing convalescents have higher frequency and broader neutralizing antibody responses against variants.

Post-glacial expansion dynamics, not refugial isolation, shaped the genetic structure of a migratory bird, the yellow warbler

The paper uses climate-informed spatial genetic modeling to show that post-glacial expansion dynamics, not refugial isolation, shaped the genetic structure of the yellow warbler.

Following the niche: reconstructing 32,000 years of niche dynamics in four European ungulate species

This study examines niche changes in four European ungulates over 32,000 years, finding that some species altered their niche post-Last Glacial Maximum, possibly due to megafauna extinctions.

mtDNA-based reconstructions of change in effective population sizes of Holarctic birds do not agree with their reconstructed range sizes based on paleoclimates

The paper uses mitochondrial DNA and bioclimatic models to compare changes in effective population size and range size in Holarctic birds, finding no correlation between the two.