Author

T. Chai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. M. Lande· 1 shared A. Valdez· 1 shared B. C. Curtis· 1 shared C. H. Spurrell· 1 shared C. Muscat· 1 shared C. P. Saxby· 1 shared C. Terrettaz· 1 shared G. Wernig· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

A. M. Lande

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genome-wide CRISPRa screens nominate modulators of CAR T cell survival within distinct tumor cytokine milieus

B. C. Curtis, C. H. Spurrell, L. Flint, A. M. Lande, M. Leonardi, J. M. Rosser, A. Valdez, N. Murren, T. Chai, M. Fitzgerald, J. Martinez-Reyes, C. P. Saxby, S. K. Oda, M. C. Jensen

This paper develops a CRISPRa-based method to identify genes enhancing CAR T cell survival in different tumor environments.

bioRxiv · Mar 16, 2024 · PreprintImmunology

Spatial coupling between DNA replication and mismatch repair in Caulobacter crescentus

T. Chai, C. Terrettaz, J. Collier

This study shows that MMR components in Caulobacter crescentus use a 1D-scanning mode to detect mismatches, with MutL's spatial association with the replisome being critical for MMR efficiency.

bioRxiv · Jul 13, 2020Microbiology

CD47 prevents the elimination of diseased fibroblasts in scleroderma

T. Lerbs, L. Cui, M. King, T. Chai, C. Muscat, T. Shibata, G. Wernig

This study shows that CD47 protects scleroderma fibroblasts from immune elimination and that blocking CD47 with IL6 inhibition can reverse fibrosis in mice.

bioRxiv · Jun 6, 2020Immunology

IL-1RA controls the development of esophageal cancer by inhibition of VEGF via PI3K/NF-κB signaling pathway

Z. SHEN, S. Yu, L. Gao, Z. Liu, P. Zhang, T. Chai, S. Chen, M. Kang

This study shows IL-1RA inhibits esophageal cancer progression by suppressing VEGF through the PI3K/NF-κB pathway, suggesting it as a potential therapeutic target.

bioRxiv · Apr 30, 2019 · PreprintCancer Biology