Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses
J. Rodriguez-Ubreva, A. Arutyunyan, M. J. Bonder, L. Del Pino-Molina, S. Clark, C. de la Calle-Fabregat, L. Garcia-Alonso, L.-F. Handfield, L. Ciudad, E. Andres-Leon, F. Krueger, F. Catala-Moll, V. C. Rodriguez-Cortez, K. Polanski, L. Mamanova, , E. Ballestar
The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.
bioRxiv · Dec 20, 2021 · PreprintImmunology