E. Ballestar

Divergent Epigenetic and Transcriptomic Reprogramming of Monocyte Subpopulations in Systemic Lupus Erythematosus

This study identifies epigenetic and transcriptomic changes in SLE monocyte subsets, linking them to disease activity and function.

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

This study shows miR-574-5p activates TLR8 to drive autoimmune signaling and lupus progression by enhancing cytokine production, STAT1 activation, and autoantigen generation.

Purinergic Preconditioning Induces Epigenomic and Transcriptomic Changes Resembling Epilepsy-associated Microglial States

This study shows ATP-mediated preconditioning induces epigenomic and transcriptomic changes in microglia-like cells that resemble epilepsy-associated microglial states.

Integrated Multi-omics Analyses of NFKB1 patients B cells points towards an up regula-tion of NF-κB network inhibitors

This study identifies epigenetic and gene expression changes in B cells from NFKB1 mutation carriers, highlighting dysregulation of NF-κB network inhibitors and potential therapeutic targets.

Vitamin C triggers NF-κB-driven epigenetic reprogramming and enhanced immunogenic responses in dendritic cells

This study shows vitamin C induces epigenetic changes and enhances immunogenic responses in dendritic cells through NF-κB and TET2 interactions.

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.

MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells

This study identifies MAFB as a key mediator of GC-induced tolerogenesis in dendritic cells, showing its role in epigenomic and transcriptomic remodeling.

The JAK2-STAT pathway epigenetically regulates tolerized genes during the first encounter with bacterial antigens

The paper identifies JAK2-STAT pathway involvement in epigenetic regulation of tolerized genes during first bacterial antigen exposure, showing its role in modulating inflammatory responses.

Vitamin D receptor and STAT3 cooperate to establish TET2-mediated tolerogenesis

This study shows that VDR and STAT3 cooperate with TET2 to induce DNA demethylation and tolerogenesis in dendritic cells through vitamin D signaling.

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

This study identifies aberrant DNA methylation in mesenchymal stromal cells from myeloma patients and shows that targeting DNMTs and G9a with CM-272 reverses bone loss and reduces tumor burden.

Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction

This study investigates AID's role in DNA methylation defects in HIGM2 B cells, finding that AID is not directly involved in active demethylation but TET enzymes are, and that methylation defects are linked to premature BCR activation.