MicrobiologybioRxiv
ppGpp and RNA-Polymerase Backtracking Guide Antibiotic-Induced Mutable Gambler Cells
Y. Zhai, P. J. Minnick, J. P. Pribis…·S. M. Rosenberg
The paper identifies the stringent starvation response as a key driver of ciprofloxacin-induced mutagenesis through RNA polymerase and ppGpp-mediated DNA-damage signaling.
DOI 10.1016/j.molcel.2023.03.003