Short-term molecular consequences of chromosome mis-segregation for genome stability
L. Garribba, G. De Feudis, V. Martis, M. Galli, M. Dumont, Y. Eliezer, R. Wardenaar, M. R. Ippolito, D. R. Iyer, A. E. Tijhuis, D. C. Spierings, M. Schubert, S. Taglietti, C. Soriani, S. Gemble, , S. Santaguida
This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.
bioRxiv · Jun 19, 2022Cell Biology