Author

S. Gemble

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

F. Foijer· 3 shared R. Basto· 3 shared R. Wardenaar· 3 shared A. E. Tijhuis· 2 shared D. C. J. Spierings· 2 shared O. Goundiam· 2 shared A. Herbette· 1 shared A. Simon· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCell Biology

F. Foijer

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Author profile →

4 papers

Recent·Most cited

Centrosome amplification primes for apoptosis and favors the response to chemotherapy in ovarian cancer beyond multipolar divisions

F. Edwards, G. Fantozzi, A. Y. Simon, J.-P. Morretton, A. Herbette, A. E. Tijhuis, R. Wardenaar, S. Foulane, S. Gemble, D. C. J. Spierings, F. Foijer, O. Mariani, A. Vincent-Salomon, S. Roman-Roman, X. Sastre-Garau, , R. Basto

The paper shows centrosome amplification in ovarian cancer cells primes them for apoptosis and improves chemotherapy response, independent of multipolar divisions and chromosome instability.

bioRxiv · Jul 28, 2023 · PreprintCell Biology

Short-term molecular consequences of chromosome mis-segregation for genome stability

L. Garribba, G. De Feudis, V. Martis, M. Galli, M. Dumont, Y. Eliezer, R. Wardenaar, M. R. Ippolito, D. R. Iyer, A. E. Tijhuis, D. C. Spierings, M. Schubert, S. Taglietti, C. Soriani, S. Gemble, , S. Santaguida

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

bioRxiv · Jun 19, 2022Cell Biology

Genetic instability from a single S-phase after whole genome duplication

S. Gemble, R. Wardenaar, K. Keuper, N. Srivastava, M. Nano, A.-S. Mace, A. Tijhuis, S. V. Bernhard, D. C. J. Spierings, A. Simon, O. Goundiam, H. Hochegger, M. Piel, F. Foijer, Z. Storchova, R. Basto

This study shows that newly formed tetraploid human cells experience high DNA damage during the first S-phase, leading to abnormal karyotypes and genetic instability.

bioRxiv · Jul 16, 2021Cell Biology

Topoisomerase IIα Prevents, But Does Not Resolve, Ultrafine Anaphase Bridges By Two Mechanisms

S. Gemble, G. Buhagiar-Labarchede, R. Onclercq-Delic, S. Lambert, M. Amor-Gueret

This study shows Topo IIα prevents UFB formation during S-phase and mitosis but does not resolve UFBs during anaphase.

bioRxiv · Oct 23, 2019 · PreprintCell Biology