F. Foijer

CDK4 is co-amplified with either TP53 promoter gene fusions or MDM2 through distinct mechanisms in osteosarcoma

This study identifies four subgroups of osteosarcomas based on genomic and transcriptomic analysis, revealing distinct mechanisms of CDK4 amplification in relation to MDM2 or TP53 alterations.

CDC20 determines the sensitivity to spindle assembly checkpoint (SAC) inhibitors

The paper identifies CDC20 expression as a determinant of sensitivity to SAC inhibitors, showing that aneuploid cells with high CDC20 levels are more sensitive to these drugs.

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

Tracking genome evolution in single cell clones reveals the rates and features of copy number alterations generated by ongoing chromosomal instability in cancer.

The paper tracks genome evolution in single-cell clones to reveal copy number alteration rates and features in cancer driven by chromosomal instability.

Chronic deregulation of the spindle assembly checkpoint triggers myelosuppression and gastrointestinal atrophy

The paper investigates the effects of chronic SAC activation in mice, finding it causes bone marrow aplasia and intestinal atrophy, with BIM playing a critical role in gastrointestinal cell death.

Centrosome amplification primes for apoptosis and favors the response to chemotherapy in ovarian cancer beyond multipolar divisions

The paper shows centrosome amplification in ovarian cancer cells primes them for apoptosis and improves chemotherapy response, independent of multipolar divisions and chromosome instability.

Predicting CIN rates from single-cell whole genome sequencing data using an in silico model

The paper develops an in silico model, CINsim, to predict chromosomal instability (CIN) rates from single-cell whole genome sequencing data by simulating karyotype dynamics and validating it in mouse and human cancer models.

Short-term molecular consequences of chromosome mis-segregation for genome stability

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

A motor-based approach to induce chromosome-specific mis-segregations in human cells

This paper introduces a motor-based method to induce chromosome-specific mis-segregations in human cells, revealing how spindle forces can cause aneuploidies.

Inducing Specific Chromosome Mis-Segregation in Human Cells

This study induces specific chromosome mis-segregation in human cells using CRISPR-Cas9 to create designer karyotypes and study aneuploidy's cellular effects.

Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

The paper applies a clinically-relevant chemotherapy regimen to neuroblastoma PDX models to identify transcriptional patterns and mechanisms of chemoresistance.

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

Rapid and efficient generation of antigen-specific isogenic T cells from cryopreserved blood samples

This study demonstrates an efficient CRISPR/Cas9 protocol for modifying ex vivo human T cells without affecting viability or antigen-specific responses.

Monosomies, trisomies and segmental aneuploidies differentially affect chromosomal stability

This study investigates how different aneuploidies affect chromosomal instability in human cells, finding that trisomies increase segregation errors while monosomies do not induce CIN.

Genetic instability from a single S-phase after whole genome duplication

This study shows that newly formed tetraploid human cells experience high DNA damage during the first S-phase, leading to abnormal karyotypes and genetic instability.

TP53 loss initiates chromosomal instability in high-grade serous ovarian cancer

This study shows that TP53 loss in fallopian tube epithelial cells drives chromosomal instability through cell cycle deregulation, without requiring additional mutations.

Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice

This study shows that acute systemic loss of Mad2 in adult mice causes intestinal atrophy, weight loss, and death within 10 days due to high-grade CIN, with minimal effects on other tissues.

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

This study compares chronic and transient chromosomal instability in mice, showing that transient instability accelerates tumor formation through rapid clonal evolution.

Aneuploidy-driven genome instability triggers resistance to chemotherapy

This study shows that aneuploidy-induced genome instability helps cancer cells resist chemotherapy by enabling survival under drug pressure.

PIDDosome-induced p53-activation for ploidy restriction facilitates hepatocarcinogenesis

This study shows that PIDDosome-mediated ploidy restriction prevents hepatocellular carcinoma by reducing tumor burden and that low ploidy predicts poor survival in HCC patients.

Dysregulated gene expression through TP53 promoter swapping in osteosarcoma

This study investigates how TP53 promoter swapping in osteosarcoma leads to dysregulated gene expression and oncogenic activation.

Altering microtubule dynamics is synergistically toxic with inhibition of the spindle checkpoint

The paper identifies synergistic toxicity between microtubule dynamics alteration and SAC inhibition in aneuploid cells.

Single cell DNA sequencing reveals distinct molecular types of basal cell carcinoma with unique transcriptome features

This study uses single-cell DNA sequencing to identify distinct molecular types of basal cell carcinoma based on karyotype heterogeneity and associated transcriptome features.

Non-Random Mis-Segregation of Human Chromosomes.

The paper shows that human chromosome mis-segregation is non-random, with specific chromosomes showing higher rates of aneuploidy due to cohesion fatigue.

Molecular basis of mitotic decline during human aging

This study identifies aneuploidy as a driver of mitotic decline in aging by showing FoxM1 repression leads to chromosome segregation defects and senescence.