Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells
L. Gerosa, C. Chidley, F. Froehlich, G. Sanchez, S. K. Lim, J. Muhlich, J.-Y. Chen, G. J. Baker, D. Schapiro, T. Shi, L. Yi, C. D. Nicora, A. Claas, D. A. Lauffenburger, W.-J. Qian, , P. K. Sorger
The paper shows that sporadic ERK pulses in BRAFV600E melanoma cells drive non-genetic resistance to RAF/MEK inhibitors.
bioRxiv · Sep 8, 2019Cancer Biology