Author

F. Froehlich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell signaling & trafficking· 5 Research Focus:cell type annotation· 5 Assay:proteomics· 4 Organism:yeast· 4 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Organism:human· 2

Frequent Co-Authors

S. Walter· 4 shared C. Ungermann· 3 shared S. Eising· 3 shared A. Moeller· 2 shared A. Perz· 2 shared B. M. Esch· 2 shared C. Koenig· 2 shared D. Shvarev· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

S. Walter

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Structure of the endosomal CORVET tethering complex

D. Shvarev, C. Koenig, N. Susan, L. Langemeyer, S. Walter, A. Perz, F. Froehlich, C. Ungermann, A. Moeller

The paper solves the structure of the CORVET tethering complex using cryo-EM and explains its role in promoting endosome fusion through interactions with Rab5 and PI3P.

bioRxiv · Oct 13, 2023Biochemistry

Complex Sphingolipid Profiling and Identification of an Inositol Phosphorylceramide Synthase in Dictyostelium discoideum

S. A. Listian, M. Kol, E. Ufelmann, S. Eising, F. Froehlich, S. Walter, J. C. M. Holthuis, C. Barisch

This study identifies an inositol phosphorylceramide synthase in Dictyostelium discoideum, revealing its sphingolipid biosynthesis pathway and localization.

bioRxiv · Jul 7, 2023 · PreprintCell Biology

Ferroptosis-Protective Membrane Domains in Quiescence

A. H. Megarioti, A. Athanasopoulos, D. Koulouris, B. M. Esch, M. Makridakis, V. Lygirou, M. Samiotaki, J. Zoidakis, V. Sophianopoulou, B. Andre, F. Froehlich, C. Gournas

This study identifies FLPs as ferroptosis-protective membrane domains in yeast quiescence, preventing lipid peroxidation and promoting cell survival.

bioRxiv · Apr 27, 2023Cell Biology

Structure of the lysosomal membrane fusion machinery

D. Shvarev, J. Schoppe, C. Koenig, A. Perz, N. Fuellbrunn, S. Kiontke, L. Langemeyer, D. Januliene, K. Schnelle, D. Kuemmel, F. Froehlich, A. Moeller, C. Ungermann

This study determines the structure of HOPS, a lysosomal fusion machinery, revealing its rigid architecture and how it couples membrane tethering with SNARE assembly to facilitate fusion.

bioRxiv · May 5, 2022 · PreprintBiophysics

LyTS: A Lysosome Localized Complex of TMEM192 and STK11IP

B. Angarola, F. Froehlich, S. M. Ferguson

The paper identifies TMEM192 and STK11IP as forming a lysosome-localized complex, LyTS, essential for lysosome homeostasis.

bioRxiv · Aug 27, 2021 · PreprintCell Biology

A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathways

S. Eising, B. M. Esch, M. Waelte, P. Vargas Duarte, S. Walter, C. Ungermann, M. Bohnert, F. Froehlich

The paper generates a lysosomal biogenesis map in yeast by combining proteomics and mutant analyses, revealing cargo-receptor relationships and novel CVT pathway cargo.

bioRxiv · Jul 24, 2021Cell Biology

Phosphorylation of the GARP Subunit Vps53 by Snf1 Leads to the Formation of a Golgi-Mitochondria Contact Site (GoMiCS) in Yeast

S. A. Wycislo, C. Sundag, S. Walter, S. Schuck, F. Froehlich

bioRxiv · Jun 26, 2020 · PreprintCell Biology

Multiple roles for the ESCRT machinery in maintaining plasma membrane homeostasis

O. Schmidt, Y. Weyer, S. Sprenger, M. A. Widerin, S. Eising, V. Baumann, M. Angelova, R. Loewith, C. J. Stefan, M. W. Hess, F. Froehlich, D. Teis

This study investigates the role of ESCRT machinery in plasma membrane homeostasis using budding yeast, revealing its involvement in membrane tension regulation and sphingolipid metabolism through calcineurin/TORC2 signaling.

bioRxiv · Feb 25, 2020Cell Biology

Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells

L. Gerosa, C. Chidley, F. Froehlich, G. Sanchez, S. K. Lim, J. Muhlich, J.-Y. Chen, G. J. Baker, D. Schapiro, T. Shi, L. Yi, C. D. Nicora, A. Claas, D. A. Lauffenburger, W.-J. Qian, , P. K. Sorger

The paper shows that sporadic ERK pulses in BRAFV600E melanoma cells drive non-genetic resistance to RAF/MEK inhibitors.

bioRxiv · Sep 8, 2019Cancer Biology