NLRP3 controls ATM activation in response to DNA damage.
V. PETRILLI, M. Bodnar-Wachtel, A.-L. Huber, J. Gorry, S. Hacot, L. Gerossier, B. Guey, N. Goutagny, B. Bartosch, E. Ballot, F. Ghiringhelli, B. Py, Y. Coute, A. Ballesta, S. Lantuejoul, J. Hall
This study shows NLRP3 interacts with ATM to regulate DNA damage response, and its loss reduces ATM activation and confers resistance to genomic stress in NSCLC.
bioRxiv · May 12, 2020Cancer Biology