Y. Coute

AtVPS13M1 is involved in lipid remodeling in low phosphate and is located at the mitochondria surface in plants

This study identifies AtVPS13M1 as a lipid transporter in Arabidopsis thaliana that affects phospholipid degradation during phosphate starvation and localizes to mitochondria.

Deciphering the phospho-signature induced by hepatitis B virus in primary human hepatocytes

This study identifies phosphorylation changes in host proteins induced by HBV infection in primary human hepatocytes, revealing an intrinsic anti-viral response involving DNA repair and RNA-binding proteins.

Photoreceptor-induced LHL4 protects photosystem II in Chlamydomonas reinhardtii

This study identifies LHL4 as a photoprotective protein in Chlamydomonas reinhardtii that prevents photodamage to photosystem II by binding its monomeric form and reducing singlet oxygen accumulation.

Proteomics-based characterization of ribosome heterogeneity in adult mouse organs

This study characterizes ribosome heterogeneity in adult mouse organs using proteomics, revealing tissue-specific ribosomal protein (RP) signatures and translational regulation of RP expression.

Phototropin connects blue light perception to starch metabolism in green algae

The paper identifies a blue light signaling pathway in green algae that inhibits starch accumulation via PMSK1 dephosphorylation and GAP1 repression.

The α/β hydrolase domain-containing protein 1 (ABHD1) acts as a lysolipid lipase and is involved in lipid droplet formation

This paper identifies ABHD1 as a lysolipid lipase involved in lipid droplet formation through enzymatic and structural actions on the LD surface in Chlamydomonas.

Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis

This study identifies SMYD2 as a master regulator of breast cancer metastasis and shows that targeting the SMYD2-BCAR3-FMNL axis can prevent metastatic spread.

Huntingtin bundles and changes the local proteome of actin filaments in neurons

This study shows that Huntingtin (HTT) binds to F-actin, bundles actin filaments, and modulates the association of Drebrin1 with actin, affecting axonal growth and cytoskeletal organization in neurons.

Pseudomonas aeruginosa MipA-MipB envelope proteins act as new sensors of polymyxin

This study identifies MipA and MipB as polymyxin sensors in Pseudomonas aeruginosa that activate a stress response to enhance antibiotic resistance.

Molecular crosstalk between plant translation initiation complexes influences the outcome of virus infection

This study investigates how eIF4E1 influences plant resistance to potyviruses, finding that its inactivation can lead to increased susceptibility to some viruses while conferring resistance to others.

Functional redundancy revealed by the deletion of the mimivirus GMC-oxidoreductase genes

The study shows that deleting GMC-oxidoreductase genes in mimiviruses does not impair genomic fiber or fibril layer formation, indicating functional redundancy.

Oxidation-sensitive cysteines drive IL-38 amyloid formation

This study identifies oxidation-sensitive cysteines in IL-38 that drive amyloid formation under oxidative stress, suggesting a new biological role for IL-38 in epithelial barriers.

Cell type-specific control of secondary cell wall formation by Musashi-type translational regulators in Arabidopsis

This study identifies MSIL2 and MSIL4 as cell type-specific regulators of secondary cell wall formation in Arabidopsis by controlling mRNA translation and biosynthetic gene expression.

Proteomic analyses of the Arabidopsis cap-binding complex define core set and TOR-dependent protein components

The paper identifies core and TOR-dependent components of the Arabidopsis cap-binding complex through proteomic analyses under various conditions affecting translation.

In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming

This study shows that AP2XII-1 and AP2XI-2 transcription factors reprogram Toxoplasma gondii tachyzoites to merozoites in vitro, enabling the production of pre-sexual stages without using cats.

Proteomics unveil a central role for peroxisomes in butyrate assimilation of the heterotrophic Chlorophyte alga Polytomella sp.

The paper identifies peroxisomes as central to butyrate assimilation in Polytomella sp. through proteomics, revealing β-oxidation and metabolic pathway adaptations.

A plastidial DEAD box RNA helicase plays a critical role in high light acclimation by modulating ribosome biogenesis in Chlamydomonas reinhardtii

This study identifies CreRH22, a plastidial DEAD-box RNA helicase, as essential for high light acclimation in Chlamydomonas reinhardtii by enhancing ribosome biogenesis.

Three-dimensional envelope and subunit interactions of the plastid-encoded RNA polymerase from Sinapis alba

This study determines the 3D structure of the plastid-encoded RNA polymerase (PEP) from Sinapis alba and identifies subunit interactions through proteomics and electron microscopy.

The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield

The paper reveals the Mimivirus genome is organized into a 30 nm helical protein shell with super-helical DNA strands and a central channel accommodating transcription machinery.

A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria

This paper identifies altiratinib as a selective inhibitor of PRP4K/CLK3 kinases in apicomplexan parasites, showing broad-spectrum antiparasitic activity against toxoplasmosis and malaria.

Constrained G4 structures unveil topology specificity of known and new G4 binding proteins

The paper identifies topology-specific G4-binding proteins using constrained G4 structures and reveals new interactions, including the NELF complex's role in G4-ligand effects.

A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental genes partitioning in Toxoplasma

This paper identifies an m6A-dependent polyadenylation mechanism in Toxoplasma gondii that prevents transcriptional read-through and maintains transcriptome integrity, similar to a plant mechanism.

Extracellular riboflavin induces anaerobic biofilm formation in Shewanella oneidensis

This study shows that riboflavin acts as a quorum sensing molecule in Shewanella oneidensis, triggering anaerobic biofilm formation at a specific threshold concentration.

Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production

This study identifies SRSF10 as a host RNA-binding protein that restricts HBV RNA production by interacting with the HBV core protein in the nucleus of infected hepatocytes.

The PopN gate-keeper complex acts on the ATPase PscN to regulate the T3SS secretion switch from early to middle substrates in Pseudomonas aeruginosa

The paper investigates the interaction of the T3SS ATPase PscN with secreted proteins and proposes a new role for the gate-keeper complex in regulating secretion switching from early to middle substrates in P. aeruginosa.

NLRP3 controls ATM activation in response to DNA damage.

This study shows NLRP3 interacts with ATM to regulate DNA damage response, and its loss reduces ATM activation and confers resistance to genomic stress in NSCLC.

Commensalism in the Mimiviridae giant virus family

This study investigates the interaction network between a virophage, transpovirons, and their host giant viruses, revealing a form of commensalism where transpovirons use virophages to propagate without affecting the host virus's infectious cycle.

A behavior-manipulating virus relative as a source of adaptive genes for parasitoid wasps

This paper identifies a virus as the origin of behavior-manipulating viral-like particles in parasitoid wasps and shows the virus is still transmitted and manipulates wasp behavior.

Molecular flux control encodes distinct cytoskeletal responses by specifying SRC signaling pathway usage.

The paper uses optogenetic control of SRC kinase to show that distinct cytoskeletal responses are encoded by spatial and temporal molecular fluxes of the same signaling protein.

Pandoravirus celtis illustrates the microevolution processes at work in the giant Pandoraviridae genomes

The paper analyzes the Pandoravirus celtis genome to test the hypothesis that new protein-coding genes arise de novo from non-coding regions, finding ORFans and transposase insertions.