Author

L. Grosse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Emelyanov· 2 shared A. J. Fornace· 1 shared A. Pierantoni· 1 shared B. B. Grigorash· 1 shared B. Grigorash· 1 shared B. Kanzler· 1 shared B. Seitz-Polski· 1 shared C. Bernhard· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. Emelyanov

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

p16High immune cell - controlled disease tolerance as a broad defense and healthspan extending strategy

F. Triana-Martinez, A. Pierantoni, D. Graca, V. Bergo, A. Emelyanov, B. Grigorash, S. Tsuji, S. Nakano, L. Grosse, V. Brglez, P. Marty, J. Dellamonica, A. J. Fornace, E. Trompouki, H. Eiji, , D. V. Bulavin

This study identifies p16High immune cells as critical for disease tolerance, showing they enhance survival in various conditions and extend healthspan by maintaining low adenosine levels.

bioRxiv · Jul 15, 2024Cell Biology

p16High senescence restricts totipotent potential during somatic cell reprogramming

B. B. Grigorash, D. van Essen, L. Grosse, A. Emelyanov, B. Kanzler, C. Molina, E. Lopez, O. N. Demidov, C. Garrido, S. Saccani, D. Bulavin

This study shows that removing p16High senescent cells enhances 4F-induced reprogramming of somatic cells into totipotent-like stem cells by modulating NNMT and SAM levels.

bioRxiv · Aug 24, 2022 · PreprintCell Biology

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells

M. Zwick, T. Ulas, Y.-L. Cho, C. Ried, L. Grosse, C. Simon, C. Bernhard, D. H. Busch, J. L. Schulze, V. Buchholz, S. Stutte, T. Brocker

This study shows that Ppef2 deficiency in CD8+ dendritic cells leads to increased apoptosis and reduced antigen presentation, impacting T cell responses.

bioRxiv · Jul 29, 2018Immunology