Cancer BiologybioRxivPreprint
Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells
K. Ames, I. Kaur, Y. Shi…·K. Gritsman
This study shows that deleting all three Class IA PI3K isoforms in HSCs leads to myelodysplasia through impaired autophagy, which affects differentiation and multilineage repopulation.
DOI 10.1101/2020.12.04.412593