I. Kaur

Role of maternal, fetal and placental histopathology factors in the pathogenesis of retinopathy of prematurity.

The paper investigates maternal, fetal, and placental factors predicting retinopathy of prematurity risk in preterm infants using histopathology and molecular analysis.

Collagen XVIII promotes breast cancer through EGFR/ErbB signaling and its ablation improves the efficacy of ErbB-targeting inhibitors

This study shows that collagen XVIII promotes breast cancer via EGFR/ErbB signaling and sustains cancer stem cells, and its inhibition enhances the effectiveness of ErbB-targeting therapies.

Artemisinin acts by inhibiting Plasmodium falciparum Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins

This study shows that Artemisinin inhibits Plasmodium falciparum Ddi1, leading to ubiquitinated protein accumulation and impaired damage recovery.

Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells

This study shows that deleting all three Class IA PI3K isoforms in HSCs leads to myelodysplasia through impaired autophagy, which affects differentiation and multilineage repopulation.

Generation of glucocorticoid resistant SARS-CoV-2 T-cells for adoptive cell therapy

The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.

Phosphorylation Dependent Assembly of a 14-3-3 Mediated Signaling Complex During Red Blood Cell Invasion by Plasmodium falciparum Merozoites

A systematic investigation on the involvement of complement pathway in diabetic retinopathy

This study investigates the role of the complement pathway in diabetic retinopathy, finding increased activation of the alternative pathway and co-localization of CFH with microglial cells.