K. Pradhan

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

Lagged climate-driven range shifts at species' leading, but not trailing, range edges revealed by multispecies seed addition experiment

The paper uses a seed addition experiment to test lagged climate responses and microclimatic buffering in plant range shifts, finding support for lagged responses over microclimatic buffering.

Monocytes reprogrammed by 4-PBA potently contribute to the resolution of inflammation and atherosclerosis

This study shows that 4-PBA reprograms monocytes to resolve inflammation and atherosclerosis by altering adhesion and increasing anti-inflammatory markers.

Microclimate buffering varies across forest types during an extreme heat event

The paper examines how forest microclimates buffer against extreme heat events and assesses impacts on organisms and canopy health.

Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism.

This study shows that reduced RPL22 expression in hematopoietic stem cells promotes leukemia by altering metabolism and increasing lipid synthesis via Lin28b.

Understanding inter-individual social networks in mixed-species bird flocks

This study constructs individual-level social networks in mixed-species bird flocks in the Eastern Himalaya, revealing differences in flock structure and mechanisms between two flocktypes.

Activation of targetable inflammatory immune signaling is seen in Myelodysplastic Syndromes with SF3B1 mutations

This study identifies a longer, oncogenic IRAK4 isoform caused by SF3B1 mutations in MDS/AML, which is targetable by IRAK4 inhibition.

Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells

This study shows that deleting all three Class IA PI3K isoforms in HSCs leads to myelodysplasia through impaired autophagy, which affects differentiation and multilineage repopulation.

Relationships between climate and phylogenetic community structure of fossil pollen assemblages are not constant during the last deglaciation

This study examines the stability of climate-phylogenetic community structure relationships in fossil pollen assemblages over the last 21,000 years, finding unstable slopes but stable intercepts.

Functional succinate dehydrogenase deficiency and loss of ascorbic acid transporter SLC23A1 are pathognomonic adverse features of clear cell renal cancer

This paper identifies functional succinate dehydrogenase deficiency and loss of SLC23A1 as common adverse features in clear cell renal cell carcinoma, with implications for diagnosis and treatment.

Paradoxical role of AT-rich interactive domain 1A in restraining pancreatic carcinogenesis

This study investigates the role of Arid1a in pancreatic carcinogenesis using mouse models and cell lines, finding that its loss impairs tumor growth and DNA repair but allows for later aggressive cancer development.