A. Verma

Contrast-enhanced photon-counting micro-CT of tumor xenograft models

This study evaluates contrast agents for photon-counting micro-CT in tumor xenografts, finding that Exitrone Nano 12000 provides better vasculature enhancement and consistency compared to ISOVUE-370.

A novel repressor-activator-competitor module comprising C2H2 zinc finger and NAC transcription factors regulates rice grain development

This study identifies a repressor-activator-competitor module involving ZOS1-15 and ONAC024 that regulates rice grain development through interactions with other transcription factors and co-repressors.

Differences in Methanotrophic Community Structure in Two Methane-Rich Habitats: Oil Natural Gas Field & Paddy Field

The paper identifies and characterizes two methanotrophic bacterial isolates from different methane-rich habitats, showing sequence homology and morphological differences.

Oxysterol accumulation in aging cells alters GPCR signalling

This study shows that oxysterol accumulation in aged cells disrupts CXCR4 signaling by altering G-protein coupling specificity.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments

This study uses fluorescence lifetime imaging to quantify TZM-HER2 binding and distribution in tumors with varying microenvironments, showing differences in drug delivery efficacy between cancer types.

E-proteins set the threshold for optimal TCF1 expression during αβ T cell development.

This study shows E-proteins regulate TCF1 expression thresholds during T cell development, with EPE3 being critical for TCF1 levels and T cell differentiation.

ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expression

This study identifies ACSL4 as a driver of TNBC metastasis by enhancing histone acetylation and SNAIL expression through metabolic and epigenetic mechanisms.

p38-MAPK is prerequisite for the synthesis of SARS-CoV-2 protein

This study shows that p38-MAPK is essential for SARS-CoV-2 replication, as its inhibition reduces viral growth and its activation supports RNA/protein synthesis without affecting viral entry or budding.

Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic state

The paper shows ApoE modifies Aβ oligomers to a more toxic form, detectable in live cells, and presents a potential assay for AD drug discovery.

Distinct composition of plasma virome in HIV-infected subjects on antiretroviral therapy compared to controls

This study compares the plasma virome of HIV-infected patients on antiretroviral therapy with controls, finding significant differences in viral composition.

Elucidation of the essentiality of lumazine synthase (RibH) for Mycobacterium tuberculosis survival and discovery of potent inhibitors for enhanced antimycobacterial therapy

This study validates the essentiality of RibH in M. tb survival and identifies three potent RibH inhibitors that show antimycobacterial activity and synergy with first-line TB drugs.

Tailoring Tfh Profiles Enhances Antibody Persistence to a Clade C HIV-1 Vaccine in Rhesus Macaques

This study shows that inducing GC Tfh1 cells with MPLA+QS-21 adjuvant leads to higher and longer-lasting HIV-1 Env antibodies in rhesus macaques compared to CAF01.

Cardiomyocyte-specific adenylyl cyclase type-8 overexpression induces activation of RelA together with myocardial and systemic inflammation

This study shows that overexpressing adenylyl cyclase type-8 in cardiomyocytes activates RelA and causes myocardial and systemic inflammation, leading to accelerated aging and reduced lifespan.

Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism.

This study shows that reduced RPL22 expression in hematopoietic stem cells promotes leukemia by altering metabolism and increasing lipid synthesis via Lin28b.

An efficient hairy root system for genome editing of a β-ODAP pathway gene in Lathyrus sativus

This paper develops a hairy root system for genome editing of the LsOCS gene in Lathyrus sativus to study its role in β-ODAP production and oxalate accumulation.

A Suite of Mouse Reagents for Studying Amelogenesis

The paper develops and validates twelve mouse alleles to study ameloblast differentiation stages and enamel formation, enabling targeted analysis of enamel matrix proteins and their roles in development.

PERK arm of UPR selectively regulates ferroptosis in colon cancer cells by modulating the expression of SLC7A11 (System Xc-)

This study shows that PERK inhibition reduces SLC7A11 expression and sensitizes colon cancer cells to ferroptosis, suggesting PERK inhibitors as potential therapeutics.

Modulated protein-sterol interactions drive oxysterol-induced impaired CXCR4 signalling

This study investigates how oxysterols impair CXCR4 signaling by disrupting cholesterol-protein interactions and altering signaling residue conformations.

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

This study evaluates a new live-attenuated LSD vaccine, showing it is safe, immunogenic, and effective in protecting cattle against LSD with high seroconversion rates.

Genome characterization of monkeypox cases detected in India: Identification of three sub clusters among A.2 lineage

The paper analyzes Monkeypox virus genomes from India, identifying three subclusters within the A.2 lineage and additional APOBEC3 mutations.

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer

The paper shows that mineralization in bone matrix models inhibits tumor cell proliferation and induces a stem-like phenotype, contradicting the assumption that rigidity promotes metastasis.

Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer.

This paper shows that inhibiting MALAT1 increases sensitivity to PARP inhibitors in prostate cancer by impairing homologous recombination.

B cell receptor repertoire analysis unveils dynamic antibody response and severity markers in COVID-19 patients

The paper analyzes B cell receptor repertoires in COVID-19 patients to identify antibody response dynamics and severity markers.

Activation of targetable inflammatory immune signaling is seen in Myelodysplastic Syndromes with SF3B1 mutations

This study identifies a longer, oncogenic IRAK4 isoform caused by SF3B1 mutations in MDS/AML, which is targetable by IRAK4 inhibition.

Heparan Sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

This study shows that heparan sulfate-dependent RAGE oligomerization is essential for RAGE signaling and demonstrates a monoclonal antibody that blocks this interaction.

Novel modification of Luminex assay for characterization of extracellular vesicle populations in biofluids.

This paper introduces a novel Luminex-based immunoassay for multiplexed detection of EV surface proteins without requiring EV purification, demonstrating its ability to differentiate EVs from erythrocytes, macrophages, and neurons.

A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation

The paper identifies a nuclear cAMP microdomain that suppresses tumor growth by inhibiting YAP in the Hippo pathway.

Chromosome 1q amplification perturbs a ceRNA network to promote melanoma metastasis

The paper shows that chromosome 1q amplification promotes melanoma metastasis by overexpressing ceRNAs that sequester tumor suppressor miRNAs.