Author

L. H. Chamberlain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

N. C. O. Tomkinson· 3 shared C. Salaun· 2 shared J. Greaves· 2 shared A. Galindo· 1 shared H. J. Spence· 1 shared H. Takizawa· 1 shared I. Sugimoto· 1 shared J. Batista· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

N. C. O. Tomkinson

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3 papers

Recent·Most cited

Cell BiologybioRxivMar 17, 2022

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation

C. Salaun, H. Takizawa, A. Galindo…·L. H. Chamberlain

This study develops a FRET-based high-throughput screen to identify inhibitors of zDHHC2 auto-acylation, discovering two tetrazole compounds that inhibit both auto-acylation and substrate S-acylation.

DOI 10.1016/j.jbc.2022.102469

humanexperimental assay

𝕏 PostBluesky

Cell BiologybioRxivJan 21, 2020

The Linker Domain of SNAP25 Acts as a Flexible Molecular Spacer to Ensure Efficient S-Acylation

C. Salaun, J. Greaves, N. C. O. Tomkinson, L. H. Chamberlain

This study shows that the flexible linker in SNAP25 ensures efficient S-acylation by coupling enzyme-substrate interaction with the acylation process.

DOI 10.1074/jbc.ra120.012726

humanproteomics

𝕏 PostBluesky

Cell BiologybioRxivNov 29, 2017

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

L. Fort, J. Batista, P. A. Thomason…·L. M. Machesky

This study identifies CYRI proteins as local inhibitors of Scar/WAVE-induced lamellipodia that bind to active Rac1, regulating protrusion size and complexity.

DOI 10.1038/s41556-018-0198-9

experimental assaycell signaling & trafficking

𝕏 PostBluesky