Author

L. Hamborg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 4 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

K. Lindorff-Larsen· 3 shared K. Teilum· 3 shared A. S. G. Larsen· 2 shared A. T. Nielsen· 2 shared B. Frolund· 2 shared C. L. Gee· 2 shared J. Kuriyan· 2 shared L. E. Pedersen· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

K. Lindorff-Larsen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

D. Narayanan, A. S. G. Larsen, S. J. Gauger, R. Adafia, R. B. Hammershoi, L. Hamborg, J. Bruus-Jensen, N. Griem-Krey, C. L. Gee, B. Frolund, M. M. Stratton, J. Kuriyan, J. S. Kastrup, A. E. Langkilde, P. Wellendorph, S. M. O. Solbak

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

bioRxiv · Mar 26, 2024 · PreprintBiophysics

Synergistic stabilization of a double mutant in CI2 from an in-cell library screen

L. Hamborg, D. Granata, J. G. Olsen, J. V. Roche, L. E. Pedersen, A. T. Nielsen, K. Lindorff-Larsen, K. Teilum

The paper identifies two stabilizing variants of barley chymotrypsin inhibitor 2, showing synergistic effects in a double mutant.

bioRxiv · Dec 1, 2020Biophysics

GHB confers neuroprotection by stabilizing the CaMKIIα hub domain

U. Leurs, A. B. Klein, E. D. McSpadden, N. Griem-Krey, S. M. Solbak, J. Houlton, I. S. Villumsen, S. B. Vogensen, L. Hamborg, S. J. Gauger, L. B. Palmelund, A. S. G. Larsen, M. A. Shehata, C. D. Kelstrup, J. V. Olsen, , P. Wellendorph

This study shows that GHB stabilizes the CaMKII hub domain, providing neuroprotection in cellular and mouse models.

bioRxiv · Sep 28, 2020 · PreprintBiochemistry

A dual-reporter system for investigating and optimizing protein translation and folding in E. coli

A. Zutz, L. Hamborg, L. E. Pedersen, M. M. Kassem, E. Papaleo, A. Koza, M. J. Herrgard, K. Teilum, K. Lindorff-Larsen, A. T. Nielsen

This paper introduces a dual-reporter system to assess protein translation and folding in E. coli, validated on five proteins with good correlation between reporter signals and protein expression/solubility.

bioRxiv · Sep 18, 2020Biochemistry

Global analysis of protein stability by temperature and chemical denaturation

L. Hamborg, E. W. Horsted, K. E. Johansson, M. Willemoës, K. Lindorff-Larsen, K. Teilum

This paper introduces a method to assess protein stability using combined temperature and denaturant unfolding with minimal protein requirements, demonstrating its applicability for small-scale protein purification.

bioRxiv · Apr 20, 2020Biophysics