Cancer BiologybioRxiv
Characterization of new highly selective pyrazolopyrimidine inhibitor of CDK7
M. Kovalova, L. Havlicek, S. Djukic…·V. Krystof
This paper characterizes a new CDK7 inhibitor, LGR6768, showing nanomolar potency and selectivity, with structural and cellular evidence supporting its mechanism and therapeutic potential.
DOI 10.1016/j.biopha.2023.114492