Author

L. Higa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Tanuri· 2 shared A. Ferreira· 1 shared A. N. A. Goncalves· 1 shared A. W. Schutte· 1 shared C. Caloba· 1 shared C. de Freitas· 1 shared C. Sacramento· 1 shared F. Bozza· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

A. Tanuri

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Polycomb Repressive Complex 1 subunit Cbx4 positively regulates effector responses in CD8 T cells

G. A. Melo, T. Xu, C. Caloba, A. W. Schutte, G. Brum, T. O. Passos, L. Higa, A. N. A. Goncalves, A. Tanuri, J. P. B. Viola, M. B. F. Werneck, H. Nakaya, M. E. Pipkin, G. J. Martinez, R. M. Pereira

This study shows that Cbx4 promotes effector CD8 T cell differentiation through SUMOylation and chromodomain mechanisms, impacting memory cell formation during viral infection.

bioRxiv · Oct 3, 2022 · PreprintImmunology

Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

C. de Freitas, L. Higa, C. Sacramento, A. Ferreira, P. Reis, R. Delvecchio, F. Monteiro, G. Barbosa-Lima, Y. Vieira, M. Mattos, L. Hoelz, R. Leme, M. Bastos, F. Bozza, P. Bozza, , T. Souza

This study shows that sofosbuvir inhibits Yellow fever virus replication in vitro and protects mice from infection, suggesting it as a potential therapeutic option.

bioRxiv · Feb 15, 2018Microbiology