ImmunologybioRxiv
Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4+ and CD8+ T Cells and Protects Against Recurrent Genital Herpes
L. BenMohamed, A. Quadiri, S. Prakash…·H. Schaefer
This study shows that a prime/pull vaccine using HSV-2 RR2 protein and CXCL11 chemokine boosts CD4+ and CD8+ T cells in DRG and VM tissues, reducing recurrent genital herpes severity and frequency.
DOI 10.1128/jvi.01596-23