Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4+ and CD8+ T Cells and Protects Against Recurrent Genital Herpes
L. BenMohamed, A. Quadiri, S. Prakash, N. Dhanushkodi, M. Singer, L. Zayou, A. M. Shaik, M. Sun, B. Suzer, L. Hirao, A. Chilukurri, H. Vahed, H. Schaefer
This study shows that a prime/pull vaccine using HSV-2 RR2 protein and CXCL11 chemokine boosts CD4+ and CD8+ T cells in DRG and VM tissues, reducing recurrent genital herpes severity and frequency.
bioRxiv · Aug 8, 2023Immunology