Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor
L. J. Olson, S. Misra, M. Ishihara, K. Battaile, O. C. Grant, A. Sood, R. J. Woods, J.-J. P. Kim, M. Tiemeyer, G. Ren, J. Sharp, N. M. Dahms
This study investigates how the CI-MPR receptor binds and releases carbohydrates through allosteric domain cooperativity using biophysical methods and crystal structures.
bioRxiv · Feb 21, 2020Biochemistry