G. Ren

A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort

The paper validates 12 biomarkers from a small T1D cohort using data augmentation, identifying 7 significantly altered markers linked to T1D risk.

Tertiary structure of single-instant RNA molecule reveals folding landscape

The paper uses cryo-electron tomography to study the folding landscape of an RNA origami 6-helix bundle, revealing multiple conformations and a possible folding pathway.

The Omicron variant BQ.1* with mutations at positions 28,311 and 28,312 in the SARS-CoV-2 N gene have minimal impact on CDC N1 target detection

The paper evaluates the impact of double mutations in the SARS-CoV-2 N gene on CDC N1 target detection and finds minimal effect on diagnostic assay performance.

GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in early-stage colorectal tumors and predict poor clinical outcome.

The paper identifies GZMKhigh CD8+ T effector memory cells in early-stage CRC tumors, which correlate with neutrophil abundance and predict poor clinical outcomes.

Molecular Organization of the Early Stages of Nucleosome Phase Separation Visualized by Cryo-Electron Tomography

This study uses cryo-electron tomography and deep learning to visualize the molecular organization of nucleosome phase separation stages, revealing a two-step process and the role of histone H1 in condensate transformation.

MAPK Pathway Inhibition as A Rational Therapeutic Strategy for MiR-138-5p/PAQR3 Dysregulation-mediated Epirubicin Resistance in Triple-negative Breast Cancer

This study identifies PAQR3 as a predictor of epirubicin response in TNBC and shows that MAPK inhibition can reverse resistance caused by miR-138-5p-mediated PAQR3 downregulation.

Enhancing Colorimetric LAMP Amplification Speed and Sensitivity with Guanidine Chloride

This study improves colorimetric LAMP's speed and sensitivity using guanidine chloride and combined primer sets for better SARS-CoV-2 detection.

Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor

This study investigates how the CI-MPR receptor binds and releases carbohydrates through allosteric domain cooperativity using biophysical methods and crystal structures.

Biocontrol of PGPR strain Bacillus amyloliquefaciens Ba168 against Phytophthora nicotianae on tobacco

This paper evaluates the biocontrol potential of PGPR strain Ba168 against tobacco black shank caused by Phytophthora nicotianae, showing it is effective but slightly less than a chemical mixture.

3D images of Neuronal Adhesion Molecule Contactin-2 Reveal an Unanticipated Two-State Architecture

This study uses 3D imaging to reveal the dynamic two-state architecture of the CNTN2 extracellular domain, showing it exists in equilibrium between closed and open conformations.

Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial priming

The paper identifies how fibroblasts from metastatic sites modulate mitochondrial priming in tumor cells, leading to drug desensitization through inflammatory cytokine secretion.