A. Sood

Preserving condensate structure and composition by lowering sequence complexity

This paper extends the stickers and spacers model to show that specific sticker-sticker interactions drive structured condensates, while non-specific spacer interactions lead to disorganized condensates, suggesting evolutionary pressure for low complexity domains in IDPs.

Planar Amorphous Silicon Carbide Microelectrode Arrays for Chronic Recording in Rat Motor Cortex

This study evaluates ultrathin amorphous silicon carbide microelectrode arrays for chronic neural recording in rats, showing minimal foreign body response and sustained single-unit activity over 16 weeks.

ATF4 Expression in Thermogenic Adipocytes is Required for Cold-Induced Thermogenesis in Mice via FGF21-Independent Mechanisms

This study shows ATF4 is essential for cold-induced thermogenesis in mice through amino acid metabolism, independent of FGF21, while FGF21 is not required for thermoregulation.

Coupling chromatin folding with histone modifications reveals dynamical asymmetry in the epigenetic landscape

The paper introduces a kinetic model to study how chromatin folding and histone modifications influence epigenetic stability through dynamic asymmetry.

Human Digital Twin: Automated Cell Type Distance Computation and 3D Atlas Construction in Multiplexed Skin Biopsies

The paper develops a 3D workflow to analyze multiplexed skin biopsy data, revealing age-related changes in DNA repair and immune cell ratios.

Pre-existing chromatin accessibility and gene expression differences among naïve CD4+ T cells influence effector potential

The paper shows pre-existing transcriptional and chromatin differences in naive CD4+ T cells influence their effector lineage potential.

An atlas of inter- and intra-tumor heterogeneityof apoptosis competency in colorectal cancertissue at single cell resolution

The paper generates an atlas of apoptosis susceptibility heterogeneity in colorectal cancer using single-cell analysis and ODE modeling, identifying intrinsic cellular differences in apoptosis competency.

Rapid adaptation and remote delivery of undergraduate research training during the COVID 19 Pandemic

This paper describes a remote research training program developed during the COVID-19 pandemic to support undergraduate students' academic and personal development, showing improvements in confidence, resilience, and happiness.

Stratification Of Chemotherapy-Treated Stage III Colorectal Cancer Patients Using Multiplexed Imaging And Single Cell Analysis Of T Cell Populations

This study uses multiplexed imaging and single-cell analysis to classify immune cells in stage III colorectal cancer patients, finding that multi-marker Treg classification better predicts survival than single markers.

Quantifying Epigenetic Stability with Minimum Action Paths

The paper develops a mathematical framework to analyze epigenetic stability using stochastic reaction networks and applies it to a chromatin state model to identify bistability and transition paths.

Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor

This study investigates how the CI-MPR receptor binds and releases carbohydrates through allosteric domain cooperativity using biophysical methods and crystal structures.

Helicobacter small RNA regulates host adaptation and carcinogenesis

This study identifies HPnc4160, a small RNA in H. pylori, that negatively regulates host adaptation and gastric cancer by modulating gene expression and bacterial colonization.

Quantitative Protein Topography Measurements By High Resolution Hydroxyl Radical Protein Footprinting Enable Accurate Molecular Model Selection

This paper introduces HR-HRPF to measure solvent accessible surface area and evaluates its ability to distinguish accurate molecular models.