Author

L. John

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. H. Baker· 1 shared A. H. Larsen· 1 shared A. Lemckert· 1 shared A. M. Cannon· 1 shared A. M. Minns· 1 shared A. Ramachandran· 1 shared A. Sturtz· 1 shared C. Caloba· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperImmunology

A. H. Baker

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection.

C. Caloba, A. Sturtz, T. A. Lyons, L. John, A. Ramachandran, A. M. Minns, A. M. Cannon, J. P. Whalley, T. H. Watts, M. Kaplan, S. E. Lindner, R. Vijay

This study shows that 4-1BB stimulation enhances memory B cell formation and recall responses during Plasmodium infection, improving protection against reinfection.

bioRxiv · Sep 12, 2023 · PreprintImmunology

Human AdV-20-42-42, a promising novel adenoviral vector for gene therapy and vaccine product development

M. Z. Ballmann, S. Raus, R. Engelhart, G. L. Kajan, C. van der Zalm, T. Papp, L. John, S. Khan, J. Custers, W. A. M. Bakker, H. M. van der Schaar, N. Arnberg, A. Lemckert, M. Havenga, A. H. Baker

This paper describes the development of a novel adenoviral vector, HAdV-20-42-42, which shows promise for gene therapy and vaccination due to its low seroprevalence and effective transduction capabilities.

bioRxiv · Mar 11, 2021Immunology

Membrane-binding mechanism of the EEA1 FYVE domain revealed by multi-scale molecular dynamics simulations

M. S. P. Sansom, A. H. Larsen, L. Tata, L. John

This study uses molecular dynamics simulations to reveal how the EEA1 FYVE domain binds to PI(3)P-containing membranes through a hinge mechanism involving specific interactions and flexibility.

bioRxiv · Feb 18, 2021Biophysics

The mechanism of Hsp90-induced oligomerization of Tau

S. Weickert, M. Wawrzyniuk, L. John, S. G. D. Rüdiger, M. Drescher

This study investigates how Hsp90 induces Tau oligomerization by promoting an open conformation that exposes aggregation-prone regions, while inhibiting fibril formation.

bioRxiv · Nov 27, 2019 · PreprintBiophysics