M. Kaplan

Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP and its antibody response characterisation

This study determines the 3D structures of TcPOP in open and closed conformations using cryo-EM and evaluates its immunogenicity through antibody responses in mice.

Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection.

This study shows that 4-1BB stimulation enhances memory B cell formation and recall responses during Plasmodium infection, improving protection against reinfection.

Structural remodeling of Coxiella burnetii during its biphasic developmental cycle revealedby cryo-electron tomography

This study uses cryo-electron tomography to reveal structural changes in Coxiella burnetii during its biphasic developmental cycle, showing morphological transitions and T4BSS-associated structures.

Dynamic structural adaptations enable the endobiotic predation of bdellovibrio bacteriovorus

This study uses cryo-electron tomography to image the predation cycle of Bdellovibrio bacteriovorus, revealing structural adaptations during prey invasion and replication.

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell self-renewal, differentiation and survival

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

A novel widespread bacterial structure related to the flagellar type III secretion system

The paper identifies a novel widespread bacterial structure related to the flagellar type III secretion system, suggesting its involvement in diverse cellular functions.

STAT3 expression in dendritic cells protects mice from colitis by a gut microbiome-dependent mechanism

This study shows that STAT3 deficiency in dendritic cells leads to colitis in mice, which is dependent on the gut microbiome.

Tissue-resident CD4+ T helper cells assist protective respiratory mucosal B and CD8+ T cell memory responses

This study identifies tissue-resident CD4+ T helper (TRH) cells that support local B and CD8+ T cell memory responses in the lung after influenza infection.

Toxoplasma gondii co-opts the unfolded protein response to enhance migration and dissemination of infected host cells

This study shows Toxoplasma gondii triggers the unfolded protein response in host cells to enhance migration and dissemination of infected cells through IRE1-mediated actin remodeling.

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.

Bacterial flagellar motor PL-ring disassembly sub-complexes are widespread and ancient

The paper shows that bacterial flagellar motor PL-ring sub-complexes persist after disassembly across multiple phyla and are ancient, not recently transferred.

In vivo structure of the Legionella type II secretion system by electron cryotomography

The paper presents the first in situ structure of the Legionella T2SS using cryo-ET, revealing architectural similarities and differences with T4P and supporting the piston model for substrate extrusion.

Rapid Tilt-Series Acquisition for Electron Cryotomography

The paper introduces two methods for faster tilt-series acquisition in electron cryotomography, with trade-offs in resolution and speed.

Simulations suggest a constrictive force is required for Gram-negative bacterial cell division

The paper uses simulations to show that a constrictive force is needed for Gram-negative bacterial cell division, as cell wall remodeling alone is insufficient.

Stable sub-complexes observed in situ suggest a modular assembly pathway of the bacterial flagellar motor

The paper observes stable sub-complexes in bacterial flagellar motors using cryo-tomography, suggesting a modular assembly pathway involving independent outer- and inner-membrane sub-complexes.

The structural complexity of the Gammaproteobacteria flagellar motor is related to the type of its torque-generating stators

The paper uses cryo-electron tomography to analyze flagellar motor structures in three Gammaproteobacteria species, finding a correlation between stator type and structural complexity.