S. E. Lindner

Global Release of Translational Repression Across Plasmodiums Host-to-Vector Transmission Event

This study identifies the global release of translational repression in Plasmodium parasites during host-to-vector transmission using transcriptomics and proteomics.

Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection.

This study shows that 4-1BB stimulation enhances memory B cell formation and recall responses during Plasmodium infection, improving protection against reinfection.

Long-Read Genome Assembly and Gene Model Annotations for the Rodent Malaria Parasite Plasmodium yoelii 17XNL

This paper presents a high-quality genome assembly and gene models for Plasmodium yoelii 17XNL using long-read sequencing, revealing differences from the 17X strain.

Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model

This paper develops an intranasal nanoparticle vaccine against SARS-CoV-2 using a SpyCage scaffold decorated with RBD, showing enhanced viral clearance in Syrian hamsters without preventing infection.

Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum

The paper identifies 122 putative mitochondrial proteins in Plasmodium falciparum using proximity biotinylation and mass spectrometry, with four confirmed mitochondrial proteins of unknown function.

Direct type I Interferon signaling in hepatocytes control malaria

This study shows that direct type I interferon signaling in infected hepatocytes is necessary and sufficient to control malaria, revealing cell-autonomous immune responses.

Standard selection treatments with sulfadiazine limit Plasmodium yoelii host-to-vector transmission

This study shows sulfadiazine reduces Plasmodium yoelii transmission to mosquitoes by decreasing infection prevalence and intensity, but pABA can partially reverse its effects.

The Plasmodium NOT1-G Paralogue Acts as an Essential Nexus for Sexual Stage Maturation and Parasite Transmission

This study identifies PyNOT1-G as essential for Plasmodium sexual stage maturation and transmission, showing its role in mRNA homeostasis and gametogenesis.

Limited window for donation of convalescent plasma with high live-virus neutralizing antibodies for COVID-19 immunotherapy

The study evaluates anti-SARS-CoV-2 antibody and neutralizing titer profiles in convalescent plasma samples to determine the optimal donation window for immunotherapy.

Arhgap25 deficiency leads to decreased numbers of peripheral blood B cells and defective germinal center reactions

This study shows that Arhgap25 deficiency in mice reduces peripheral B cell numbers and impairs germinal center formation and IgG1 class switching.

Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites

This study identifies two waves of translational repression in malaria sporozoite maturation using transcriptomic and proteomic data from Plasmodium species.

Ribozyme-Mediated, Multiplex CRISPR Gene Editing and CRISPRi in Plasmodium yoelii

This paper develops CRISPR-RGR, a gene editing system for Plasmodium yoelii that enables marker-free, scar-free gene disruptions and insertions with high efficiency using ribozyme-flanked sgRNAs.

Plasmodium male gametocyte development and transmission are critically regulated by general and transmission-specific members of the CAF1/CCR4/NOT complex

This study identifies PyCCR4-1 as a key regulator of male gametocyte development and transmission in Plasmodium, showing its role in mRNA stability and parasite infectivity.