ImmunologybioRxivPreprint
Fcgamma-receptor-independent controlled activation of CD40 canonical signaling by novel therpeutic antibodies for cancer therapy
C. Reitinger, K. Beckmann, A. Carle…·S. Fischer
Novel Fc-silenced anti-CD40 antibodies activate antigen-presenting cells and humanized mice without Fcγ-receptor dependence, showing efficacy and reduced toxicity compared to existing therapies.
DOI 10.1101/2023.01.16.521736