Targeting SerpinE1 reverses cellular features of Hutchinson-Gilford progeria syndrome
G. Catarinella, C. Nicoletti, A. Bracaglia, P. Procopio, I. Salvatori, M. Taggi, A. Ferri, C. Valle, R. Canipari, P. L. Puri, L. Latella
This study identifies SerpinE1 as a therapeutic target for HGPS by showing its inhibition reverses key pathological features in patient-derived fibroblasts.
bioRxiv · Nov 5, 2021 · PreprintCell Biology