C. Valle

Targeting SerpinE1 reverses cellular features of Hutchinson-Gilford progeria syndrome

This study identifies SerpinE1 as a therapeutic target for HGPS by showing its inhibition reverses key pathological features in patient-derived fibroblasts.

Amyloid aggregation of Streptococcus mutans Cnm influences its collagen-binding activity

This study shows that Cnm, a collagen-binding protein in S. mutans, forms amyloids that lose collagen-binding activity, modulating biofilm function.

The antitumoral activity of TLR7 ligands is corrupted by the microenvironment of pancreatic tumors

This study shows that TLR7 ligands inhibit pancreatic cancer cell growth in vitro but promote tumor growth in immunocompetent mice due to increased tumor-promoting macrophages.

Colon-specific immune microenvironment regulates cancer progression versus rejection

This study shows that the colon microenvironment influences whether colorectal tumors progress or are rejected, with distinct immune signatures in each outcome.

Sofosbuvir protects Zika virus-infected mice from mortality, preventing short- and long-term sequela

This study shows sofosbuvir reduces ZIKV levels and improves survival and long-term memory in infected mice.