The origin of intestinal cancer in the context of inflammation
M. P. Verhagen, R. Joosten, M. Schmitt, N. Valimaki, A. Sacchetti, K. Rajamaki, J. Choi, P. Procopio, S. Silva, B. van der Steen, T. P. P. van den Bosch, D. Seinstra, M. Doukas, L. H. Augenlicht, L. A. Aaltonen, R. Fodde
The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.
bioRxiv · Oct 2, 2023 · PreprintCancer Biology