Changes in social behaviour with alterations of MAPK3 and KCTD13/CUL3 pathways in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders.
S. Martin Lorenzo, M. d. M. Muniz Moreno, H. Atas, M. Pellen, V. Nalesso, W. Raffelsberger, G. Prevost, L. Lindner, M.-C. Birling, S. Menoret, L. Tesson, L. Negroni, J.-P. Concordet, I. Anegon, Y. Herault
This paper creates two rat models with 16p11.2 CNVs to study social behavior and finds altered MAPK3 and CUL3 pathways with sexual dimorphism in phenotypes.
bioRxiv · Feb 11, 2023 · PreprintAnimal Behavior & Cognition