Author

L. Tesson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Animal Behavior & Cognition· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:rat· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

I. Anegon· 5 shared C. Guillonneau· 3 shared S. REMY· 3 shared V. Chenouard· 3 shared C. Usal· 2 shared J.-M. Heslan· 2 shared L.-H. Ouisse· 2 shared N. Vimond· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersImmunology

I. Anegon

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Author profile →

5 papers

Recent·Most cited

Changes in social behaviour with alterations of MAPK3 and KCTD13/CUL3 pathways in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders.

S. Martin Lorenzo, M. d. M. Muniz Moreno, H. Atas, M. Pellen, V. Nalesso, W. Raffelsberger, G. Prevost, L. Lindner, M.-C. Birling, S. Menoret, L. Tesson, L. Negroni, J.-P. Concordet, I. Anegon, Y. Herault

This paper creates two rat models with 16p11.2 CNVs to study social behavior and finds altered MAPK3 and CUL3 pathways with sexual dimorphism in phenotypes.

bioRxiv · Feb 11, 2023 · PreprintAnimal Behavior & Cognition

IL-34 deficiency impairs FOXP3+ Treg function and increases susceptibility to autoimmunity

A. Freuchet, A. Salama, S. Bézie, L. Tesson, S. Rémy, R. Humeau, H. Règue, L. Flippe, P. Peterson, N. Vimond, C. Usal, S. Ménoret, J.-M. Heslan, F. Duteille, F. Blanchard, , C. Guillonneau

This study shows IL-34 deficiency impairs FOXP3+ Treg function, leading to autoimmunity and increased susceptibility to colitis and graft rejection.

bioRxiv · Feb 4, 2022 · PreprintImmunology

CD4+ and CD8+ regulatory T cells characterization in the rat using a unique transgenic Foxp3-EGFP model.

S. MENORET, L. Tesson, S. REMY, V. Gourain, C. Serazin, C. Usal, A. Guiffes, V. Chenouard, L.-H. Ouisse, M. Gantier, J.-M. Heslan, C. Fourgeux, J. Poschmann, C. Guillonneau, I. Anegon

The paper develops a rat transgenic model with Foxp3-EGFP to study CD4+ and CD8+ regulatory T cells, revealing their frequencies, markers, suppressive activity, and transcriptome.

bioRxiv · Dec 9, 2021 · PreprintImmunology

Highly Efficient Knockin in Human iPS Cells and Rat Embryos by CRISPR/Cas9 Molecular Optimization

V. Chenouard, I. Leray, L. Tesson, S. Remy, A. Fortun, K. Bernardeau, Y. Cherifi, L. David, I. Anegon

This study optimizes CRISPR/Cas9 reagent concentrations for efficient knockin in human iPS cells and rat embryos, achieving 50% knockin efficiency with reduced costs and toxicity.

bioRxiv · Sep 3, 2021 · PreprintBioengineering

Immunological characterization of a rat model of Duchenne’s disease and demonstration of improved muscle strength after anti-CD45RC antibody treatment

L.-H. Ouisse, S. Remy, A. Lafoux, T. Larcher, L. Tesson, V. Chenouard, C. Guillonneau, L. Brusselle, N. Vimond, K. Rouger, Y. Pereon, A. Chenouard, C. Gras-Le Guen, C. Braudeau, R. Josien, , I. Anegon

This study characterizes immune responses in a rat model of Duchenne’s disease and shows that anti-CD45RC antibody treatment improves muscle strength without side effects.

bioRxiv · Sep 3, 2018Immunology