Signaling Node at TSC2 S1365 Potently Regulates T-Cell Differentiation and Improves Adoptive Cellular Cancer Therapy
D. A. Kass, J. D. Powell, C. Patel, Y. Dong, B. L. Dunkerly-Eyring, J. Wen, M. J. Ranek, L. M. Bartle, D. B. Henderson, J. Sagert
This study shows that mutating TSC2 at S1365 enhances T-cell effector function and memory formation, improving adoptive T-cell therapy for cancer.
bioRxiv · Nov 30, 2022 · PreprintImmunology