Y. Dong

Transcription factor binding site divergence across maize inbred lines drives transcriptional and phenotypic variation

The paper identifies TF binding site divergence between maize inbred lines and links it to gene expression and phenotypic variation.

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

Broad-spectrum RNA antiviral inspired by ISG15-/- deficiency

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Microbiota-dependent in vivo biotransformation, accumulation, and excretion of arsenic from arsenobetaine-rich diet

This study shows that gut microbiota in mice transform arsenobetaine into toxic arsenic species, affecting its accumulation and excretion.

Asymmetric binding of coactivator SRC1 to FXR-RXR and allosteric communication within the complex

This study reveals the asymmetric binding of SRC1 to FXR-RXR and the allosteric communication within the complex, providing a structural model for understanding FXR function and its disease implications.

Protein S-glutathionylation confers cell resistance to ferroptosis

This study shows that protein S-glutathionylation protects cells from ferroptosis by maintaining ARF6 function and reducing labile iron pools.

Exploring differences between depression and bipolar disorder through the urinary proteome

This study identifies differential proteins in urine proteomics to distinguish depression from bipolar disorder, suggesting immune-related mechanisms and potential biomarkers for diagnosis and treatment.

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

12/15-Lipoxygenases mediate neuropathic-like pain hypersensitivity in female mice

This study shows that 12/15-Lipoxygenases contribute to neuropathic-like pain hypersensitivity in female mice, with inhibitors reversing pain symptoms.

Pro-renin Receptor Inhibited ABCA1/G1 Expression Associated with Low HDL-c and Promoted Atherosclerosis

This study shows that prorenin binding to (P)RR inhibits ABCA1/ABCG1 expression and cholesterol efflux, leading to dyslipidemia and atherosclerosis in hypertension.

SHOOTMERISTEMLESS autoactivation: A prerequisite for fruit metamorphosis

The paper shows that CrSTM autoactivation through a cis regulatory element is essential for Capsella fruit shape transition during metamorphosis.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

3D Bioprinting of Human Neural Tissues with Functional Connectivity

This study develops a 3D bioprinting platform to create human neural tissues with functional connectivity, showing differentiation into neurons and astrocytes and forming functional circuits.

Dynamic evolution of the heterochromatin sensing histone demethylase IBM1

This study investigates the evolution of IBM1, an H3K9 demethylase, in flowering plants, showing its role in regulating gene body methylation and its dynamic evolution across species.

Epsins oversee smooth muscle cell reprogramming by influencing master regulators KLF4 and OCT4.

This study shows Epsins regulate smooth muscle cell reprogramming by modulating OCT4 and KLF4, with implications for coronary artery disease.

Climate change has desynchronized insect and vegetation phenologies across Europe

The paper examines phenological shifts in European vegetation and herbivorous insects over 34 years, finding that 61.2% have become asynchronous, with vegetation advancing faster than insects.

AP-1 regulates heterogeneous cellular dormancy in TNBC

The paper identifies heterogeneous subpopulations of slow-cycling cells in TNBC and shows AP-1, particularly the JunB subunit, regulates dormancy and drug resistance.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Identification of a link between splicing and endoplasmic reticulum proteostasis

This study identifies SNRPB as a regulator of ER export and links it to osteogenesis and CCMS through its effects on splicing and the UPR.

Differential effects of aneuploidy on growth and differentiation in human intestinal stem cells

This study investigates how different types of aneuploidy affect growth and differentiation in human intestinal stem cells, finding that complex aneuploidy triggers p53 activation and cell-cycle arrest, while simple aneuploidy allows continued proliferation and impaired differentiation.

Plant immunity activated and suppressed by a conserved effector protein family in mirid bug Riptortus pedestris

RPH1, a conserved HAMP in herbivorous insects, activates plant PTI responses, but R. pedestris evolved four paralogs to suppress this immunity.

Soil intake modifies the gut microbiota and alleviates ovalbumin-induced mice asthma inflammation

The paper shows that sterilized soil intake reduces asthma inflammation in mice by altering gut microbiota and shifting immune responses toward Th1.

Syntenin and CD63 Promote Exosome Biogenesis from the Plasma Membrane by Blocking Cargo Endocytosis

This study shows that syntenin and CD63 promote exosome biogenesis by blocking CD63 endocytosis, allowing it to accumulate at the plasma membrane where exosomes originate.

Sterile Soil as Prebiotics Mitigate Intergenerational Loss of Gut Microbial Diversity and Anxiety-Like Behavior Induced by Antibiotics in mice

This study shows that sterile soil prebiotics can restore gut microbial diversity and alleviate anxiety-like behavior and intestinal barrier issues caused by antibiotic exposure across generations in mice.

Semi-rational evolution of a recombinant DNA polymerase for modified nucleotide incorporation efficiency

This study improves a DNA polymerase's ability to incorporate modified nucleotides through combinatorial mutagenesis, resulting in a 20-fold efficiency gain.

Molecular understanding of anthocyanin biosynthesis activated by PAP1 in engineered red Artemisia annua cells and regulation of 2, 4-dichlorophenoxyacetic acid

The paper investigates how PAP1 activates anthocyanin biosynthesis in red Artemisia annua cells and how 2,4-D affects this process by downregulating PAP1 and pathway gene expression.

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

Conserved auxin signalling synergism through the canonical and ETT-mediated pathways promotes gynoecium development in members of the Brassicaceae

This study investigates the relationship between canonical and ETT-mediated auxin signaling pathways in Arabidopsis and Capsella, revealing conserved synergism in gynoecium development.

Metabolic engineering of anthocyanin pathway in Artemisia annua cells does not exclude the expression of artemisinin pathway

This study shows that engineering anthocyanin pathway in Artemisia annua cells does not prevent artemisinin biosynthesis, suggesting artemisinin can be produced in non-GT cells.