Evolutionary BiologybioRxiv
A direct experimental test of Ohno's hypothesis
L. Mihajlovic, B. R. Iyengar, F. Baier…·Y. Schaerli
This study experimentally tests Ohno's hypothesis by evolving fluorescent protein genes in E. coli, finding that double-copy populations show increased mutational robustness and diversity but not accelerated phenotypic evolution.
DOI 10.7554/elife.97216