ImmunologybioRxiv
Transient protein accumulation at the center of the T cell antigen presenting cell interface drives efficient IL-2 secretion
D. J. Clark, L. E. McMillan, S. L. Tan…·C. Wülfing
The paper investigates the role of the central supramolecular signaling cluster (cSMAC) in T cell activation by manipulating adaptor proteins and showing its impact on IL-2 secretion.
DOI 10.7554/elife.45789