Transient protein accumulation at the center of the T cell antigen presenting cell interface drives efficient IL-2 secretion
D. J. Clark, L. E. McMillan, S. L. Tan, G. Bellomo, C. Massoue, H. Thompson, L. Mykhaylechko, D. Alibhai, X. Ruan, K. L. Singleton, M. Du, A. J. Hedges, P. L. Schwartzberg, P. Verkade, R. F. Murphy, C. Wülfing
The paper investigates the role of the central supramolecular signaling cluster (cSMAC) in T cell activation by manipulating adaptor proteins and showing its impact on IL-2 secretion.
bioRxiv · Feb 4, 2019Immunology