STING activation depends on ACBD3 and other phosphatidylinositol 4-phosphate-regulating proteins
R. D. Luteijn, S. R. van Terwisga, J. E. Ver Eecke, L. Onia, S. A. Zaver, J. J. Woodward, D. H. Raulet, F. J. van Kuppeveld
This study identifies ACBD3 and PI4P-regulating proteins as essential for STING activation and shows that modulating PI4P levels can enhance STING signaling and cytokine production.
bioRxiv · Oct 17, 2022 · PreprintImmunology