Synergy and allostery in ligand binding by HIV-1 Nef
A. Aldehaiman, A. A. Momin, A. Restouin, L. Wang, X. Shi, S. Aljedani, S. Opi, A. Lugari, U. F. S. Hameed, L. Ponchon, X. Morelli, M. Huang, C. Dumas, Y. Collette, S. T. Arold
This study investigates how HIV-1 Nef's flexible regions interact with its core domain to influence SH3 domain selectivity and identifies few human proteins with similar binding properties.
bioRxiv · Nov 5, 2020Biophysics