Author

A. Lugari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Aldehaiman· 2 shared S. T. Arold· 2 shared X. Morelli· 2 shared A. A. Momin· 1 shared A. Restouin· 1 shared A. Sandholu· 1 shared C. Dumas· 1 shared H. Wu· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

A. Aldehaiman

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Author profile →

2 papers

Recent·Most cited

Functional selection in SH3-mediated activation of the PI3 kinase

S. S. Aljedani, A. Aldehaiman, A. Sandholu, S. Alharb, V. C. Y. Mak, H. Wu, A. Lugari, M. Jaremko, X. Morelli, J. Backer, J. E. Ladbury, M. Nowakowski, L. W. T. Cheung, S. T. Arold

This study identifies how SH3 domains activate PI3K by engaging in tertiary interactions with p85, revealing a mechanism for controlling activation through functional selection.

bioRxiv · Apr 30, 2024 · PreprintBiochemistry

Synergy and allostery in ligand binding by HIV-1 Nef

A. Aldehaiman, A. A. Momin, A. Restouin, L. Wang, X. Shi, S. Aljedani, S. Opi, A. Lugari, U. F. S. Hameed, L. Ponchon, X. Morelli, M. Huang, C. Dumas, Y. Collette, S. T. Arold

This study investigates how HIV-1 Nef's flexible regions interact with its core domain to influence SH3 domain selectivity and identifies few human proteins with similar binding properties.

bioRxiv · Nov 5, 2020Biophysics