Author

L. Raich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

F. Noe· 3 shared A. M. Klingler· 2 shared M. E. Rothenberg· 2 shared N. P. Azouz· 2 shared S. Olsson· 2 shared B. M. Henry· 1 shared C. D. Christ· 1 shared I. V. Akhrymuk· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiophysics

F. Noe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular mechanism of SARS-CoV-2 cell entry inhibition via TMPRSS2 by Camostat and Nafamostat mesylate

T. Hempel, L. Raich, S. Olsson, N. P. Azouz, A. M. Klingler, M. E. Rothenberg, F. Noe

This study investigates how camostat and nafamostat inhibit SARS-CoV-2 entry by targeting TMPRSS2 through molecular simulations and experiments, showing nafamostat's higher efficacy due to increased Michaelis complex binding.

Chemical Science · Jan 1, 2021Peer-reviewedBiophysics

Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2

N. P. Azouz, A. M. Klingler, V. Callahan, I. V. Akhrymuk, K. Elez, L. Raich, B. M. Henry, J. L. Benoit, S. W. Benoit, F. Noe, K. Kehn-Hall, M. E. Rothenberg

This study identifies alpha 1 antitrypsin (A1AT) as a TMPRSS2 inhibitor that limits SARS-CoV-2 dissemination by inhibiting extracellular proteases involved in viral entry.

bioRxiv · May 4, 2020Microbiology

Discovery of a hidden transient state in all bromodomain families

L. Raich, K. Meier, J. Günther, C. D. Christ, F. Noe, S. Olsson

The paper identifies a transient state in all bromodomain families using molecular dynamics simulations and structural data, suggesting it acts as an allosteric regulatory switch.

bioRxiv · Apr 1, 2020Biophysics