RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2
F. Vesuna, I. Akhrymuk, A. Smith…·V. Raman
This study shows that RK-33, a DDX3 inhibitor, reduces SARS-CoV-2 viral load across multiple variants in Calu-3 cells and downregulates SARS-CoV-2 genes and TMPRSS2 expression.