Author

L. Roa-Pena

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. V. Leiton· 2 shared C.-H. Pan· 2 shared K. R. Shroyer· 2 shared L. F. Escobar-Hoyos· 2 shared R. Tseng· 2 shared S. Chowdhury· 2 shared B. Chen· 1 shared K. L. Donnelly· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

C. V. Leiton

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Disassembly of embryonic keratin filaments promotes pancreatic cancer

R. R. Kawalerski, M. Torrente Goncalves, C.-H. Pan, R. Tseng, L. Roa-Pena, C. V. Leiton, L. A. Torre-Healy, T. Boyle, S. Chowdhury, N. T. Snider, K. R. Shroyer, L. F. Escobar-Hoyos

This study shows that phosphorylation of K17 promotes pancreatic cancer metastasis and shorter survival by disassembling keratin filaments and enabling nuclear translocation.

bioRxiv · Aug 27, 2022 · PreprintCancer Biology

Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

C.-H. Pan, N. Chaika, R. Tseng, M. A. Siraj, B. Chen, K. L. Donnelly, M. Horowitz, C. V. Leiton, S. Chowdhury, L. Roa-Pena, L. Oblein, N. Marchenko, P. K. Singh, K. R. Shroyer, L. F. Escobar-Hoyos

This study identifies K17-mediated pyrimidine biosynthesis as a mechanism of chemoresistance in PDAC and shows that targeting DHODH with Brequinar enhances the efficacy of chemotherapy.

bioRxiv · Aug 24, 2022Cancer Biology